The heat of the battle: inflammation's role in prostate cancer development and inflammation-targeted therapies.

ABSTRACT: In prostate cancer (PC), chronic inflammation silently guides disease progression, playing a significant role. As a major global health concern, PC contributes to high mortality rates and rising new cases worldwide, highlighting the urgent need for research into the molecular mechanisms behind this disease. Notably, the persistence of inflammation actively promotes cancer development, including in PC. This review explores the complex relationship between inflammation and PC, examining the molecular pathways, genetic and environmental factors, and clinical implications involved in inflammation-driven carcinogenesis. From cellular and molecular elements of the inflammatory microenvironment to mechanisms like epithelial-to-mesenchymal transition (EMT), reactive oxygen species (ROS) generation

SUBMITTER: Sharma U 

PROVIDER: S-EPMC11787145 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature