Cerebellar Oscillatory Patterns in Essential Tremor: Modulatory Effects of VIM-DBS.

ABSTRACT: Essential tremor (ET) is a common movement disorder, and while ventral intermediate nucleus deep brain stimulation (VIM-DBS) is a well-established treatment, its precise mechanisms or modulatory effects, particularly in relation to cerebellar oscillations, remain unclear. In this study, we hypothesized that VIM-DBS would modulate cerebellar oscillatory activity across both resting and motor task conditions, reflecting its impact on cerebello-thalamic pathways. Ten patients diagnosed with ET participated in this study. We examined the effects of VIM-DBS on mid-cerebellar oscillations during resting-state and lower-limb pedaling motor tasks. Frequency analysis was conducted on the resting-state signal and time-frequency analysis was performed on motor task-related signals. We explored the mo

SUBMITTER: Bosch TJ 

PROVIDER: S-EPMC11787153 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature