The functional TNF-α^-308G > a single-nucleotide polymorphism (rs1800629): association with the predictive indices of breast cancer carcinogenesis.

ABSTRACT:

Background

Compared with all other cancer types, Breast cancer (BC) among women has now exceeded them all as the primary reason for cancer worldwide. The BC represents 11.7% of all cancer cases and accounts for a predestined 2.3 million new cases. It is the fourth primary reason for cancer-associated deaths in women. With a staggering 200-400% increase in the relative incidence of BC in Egypt, there is an urgent need for new diagnostic or predictive markers.

Purpose

The current investigation aims to explore the connection of the functional TNF-α^-308G > A (rs1800629) single-nucleotide polymorphism (SNP) with different breast cancer predictive indices.

Methods

The ARMS-PCR method was used for genotyping TNF-α^-308G > A SNP. Three groups were recruit

SUBMITTER: Refaat S 

PROVIDER: S-EPMC11787156 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature