CKD-Associated Pruritus is Associated with Greater Use of Antidepressants and Anti-pruritus Medications.

ABSTRACT:

Introduction

Chronic kidney disease-associated pruritus (CKD-aP) is a common, yet underdiagnosed condition among patients on hemodialysis. Considering the lack of established treatment pathways, we sought to evaluate the use of antidepressant, systemic antihistamines, or gabapentinoid medications among patients with CKD-aP in the year following pruritus assessment.

Methods

We included 6209 patients on hemodialysis in the analysis. We retrospectively extracted clinical and patient-reported data from electronic health records. The intensity of CKD-aP was assessed by KDQOL-36 and 5-D Itch questionnaires. Prescription of antidepressant, antihistamine, and gabapentinoids was ascertained by the occurrence of a relevant active medical order in patients' medical records.

Results<

SUBMITTER: Ion Titapiccolo J 

PROVIDER: S-EPMC11787220 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature