Rebamipide for management of methotrexate-induced oral ulcers: a three-arm randomized clinical trial.

ABSTRACT:

Objectives

This RCT aimed to evaluate the effect of topical Rebamipide (regular and nanoparticulated) in comparison to topical Clobetasol propionate in the management of methotrexate-induced oral ulcers in rheumatoid arthritis patients.

Materials and methods

Patients were divided randomly into three parallel arms: 1% Rebamipide; 1% nanoparticulated Rebamipide, Clobetasol propionate. The outcome measures included WHO oral mucositis grading, pain (NRS), ulcer size, and healing time. The data was analyzed for any statistical significance.

Results

Intragroup comparisons of mucositis grade improvement and pain reduction revealed significant differences in all the groups. All intergroup comparisons demonstrated non-significant difference, yet nanoparticulated Rebamipide was

SUBMITTER: Abdelaziz A 

PROVIDER: S-EPMC11787234 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature