Maternal diet quality and circulating extracellular vesicle and particle miRNA during pregnancy.

ABSTRACT:

Purpose

During pregnancy, extracellular vesicle and particle microRNAs (EVP miRNA) in maternal circulation have the capacity to cross the placenta and facilitate maternal-fetal communication. Both dysregulation of circulating EVP miRNA during pregnancy and maternal diet quality have been previously associated with pregnancy complications and adverse birth outcomes. However, little is known about how maternal diet influences circulating EVP miRNA during pregnancy. This study assesses associations between maternal diet quality, as measured by the Alternative Healthy Eating Index (2010; AHEI-2010), and EVP miRNA levels in maternal circulation during pregnancy.

Methods

In a pilot study of 53 pregnant participants in the New Hampshire Birth Cohort Study, maternal diet quality was

SUBMITTER: Muse ME 

PROVIDER: S-EPMC11787256 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature