METTL3 regulates autophagy of hypoxia-induced cardiomyocytes by targeting ATG7.

ABSTRACT: N⁶-methyladenosine (m⁶A) mRNA modification is the most common mRNA internal modification in eukaryotes, which participates in a variety of biological processes. However, the role of m⁶A methylation in regulating autophagy induced by ischemia and hypoxia remains to be widely investigated. Here, we investigated the impact of METTL3, a key m⁶A methyltransferase, on the autophagy regulation in ischemic and hypoxic cardiomyocytes, as well as in mice following acute myocardial infarction (AMI). METTL3 negatively regulated autophagy in cardiomyocytes under ischemia and hypoxia conditions. Silencing METTL3 enhanced autophagy and mitigated cardiomyocyte injury, whereas overexpression of METTL3 exerted the opposite effect. Mechanistically, METTL3 methylate

SUBMITTER: Li L 

PROVIDER: S-EPMC11787298 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature