A systematised review and evidence synthesis on the broader societal impact of vaccines against Salmonella.

ABSTRACT: Vaccines against Salmonella Typhi are available, while vaccines against invasive non-typhoidal Salmonella are in development. Investments in vaccine development and introduction need to be informed by a full value of vaccines assessment, including consideration of broader societal impacts of salmonellae disease. We reviewed literature on these broader impacts in low- and middle-income countries to inform a conceptual framework. We found 16 studies relevant to Salmonella, but only one study on non-typhoidal Salmonella. Despite variations in study design, methodology, and study quality, salmonellae infections were largely associated with negative broader societal impacts, including detriments in childhood physical development (very weak association), childhood educational development (strong

SUBMITTER: Demirtas ED 

PROVIDER: S-EPMC11787315 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature