EXO1 is a key gene for lung-resident memory T cells and has diagnostic and predictive values for lung adenocarcinoma.

ABSTRACT: Lung adenocarcinoma (LUAD) is a very common and lethal kind of lung malignancy. An increasing number of studies indicated that tissue-resident memory T (T_RM) cells played significant roles in anti-cancer immunity. In our previous study, EXO1 was found to be a core gene for T_RM cells in the prognosis of LUAD. However, the roles of EXO1 in the tumor microenvironment, and its application in the diagnosis and prognosis prediction of LUAD are still inadequately explored. In this study, the RNA expression, DNA methylation, CNV, somatic mutation data of EXO1, and the corresponding patients' clinical information from publicly available databases were analyzed using bioinformatic methods. The results were validated through immunohistochemical staining of EXO1 in LUAD samples.

SUBMITTER: Li Z 

PROVIDER: S-EPMC11787328 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature