Sustainable synthesis of α-ketoglutaric and methanetriacetic acids from biomass feedstocks.

ABSTRACT: α-Ketoglutaric acid (KGA) and methanetriacetic acid (MTA) are important multi-functional carboxylic acids with versatile applications. However, their synthetic processes are still not green and efficient. Herein, we report a novel one-pot approach for sustainable synthesis of KGA and MTA from biomass-derived pyruvic and glyoxylic acids under mild conditions. KGA is synthesized via cross-aldol condensation of pyruvic and glyoxylic acids to 2-hydroxy-4-oxopentanedioic acid, followed by its sequential dehydration and hydrogenation on Pd/TiO₂, affording a high yield of 85.4% on a molar basis of glyoxylic acid at 110 °C and 1.0 MPa H₂. The synthesis of MTA involves cross-aldol condensation of KGA and glyoxylic acid to 3-(carboxymethyl)-2-hydroxy-4-oxopentanedioic acid and

SUBMITTER: Hong CB 

PROVIDER: S-EPMC11787342 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature