Association of Fontan Pathophysiology With Plasma Bile Acids.

ABSTRACT:

Background

Patients with Fontan circulation are frail and experience multisystem dysfunction including impaired exercise capacity, low resting and exercise-augmented cardiac output, and progressive liver fibrosis. However, common underlying biochemical abnormalities or disease-specific biomarkers have not been well-described.

Objectives

We wish to investigate Fontan and their matched healthy subjects using a nontargeted, followed by targeted metabolomic analysis.

Methods

Patients with Fontan circulation were compared to age- and sex-matched healthy controls with regard to body composition, markers of frailty, cardiopulmonary exercise testing, and resting and exercise-augmented hemodynamics. Subsequently, the study participants underwent a nontargeted metabolomics asse

SUBMITTER: Shah AH 

PROVIDER: S-EPMC11787425 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature