Subtle genomic differences in <i>Klebsiella pneumoniae sensu stricto</i> isolates indicate host adaptation.

ABSTRACT: Klebsiella pneumoniae sensu stricto (KpI) is an opportunistic pathogen capable of residing as a commensal in both human and bovine intestinal tracts and can cause serious systemic infections in humans and severe clinical mastitis in dairy cattle. It is unclear what role zoonotic and anthroponotic transmission play in the dissemination of KpI. In this study, we use a comparative genomic approach to identify differences between KpI associated with disease in humans and cattle and aimed to identify any potential genetic barriers limiting transmission of KpI between these two hosts. A total of 128 KpI strains (bovine n = 65; human n = 63) were whole genome sequenced and human and bovine strains were compared based on phylogenomics, the pangenome, mobile genetic elements, a

SUBMITTER: O'Brien B 

PROVIDER: S-EPMC11787494 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature