Long-term effects of dupilumab on chronic rhinosinusitis with nasal polyps: A step towards clinical remission.

ABSTRACT:

Background and objectives

Clinical remission, defined as the absence of disease activity and symptoms, is an emerging goal in the management of chronic rhinosinusitis with nasal polyps (CRSwNP). This study aimed to evaluate the long-term effects of dupilumab on patients with CRSwNP, with or without asthma, and explore the potential for achieving clinical remission.

Methods

A two-year prospective study was conducted on 109 patients with CRSwNP, with or without asthma, who were eligible for dupilumab as an add-on therapy. Comprehensive assessments, including clinical, laboratory, and radiological evaluations, were performed before and after treatment. Clinical remission of CRSwNP was defined as 12 months of dupilumab treatment, no exacerbations requiring oral corticosteroids (

SUBMITTER: Al-Ahmad M 

PROVIDER: S-EPMC11787525 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature