Endothelial calcium firing mediates the extravasation of metastatic tumor cells.

ABSTRACT: Metastatic dissemination is driven by genetic, biochemical, and biophysical cues that favor the distant colonization of organs and the formation of life-threatening secondary tumors. We have previously demonstrated that endothelial cells (ECs) actively remodel during extravasation by enwrapping arrested tumor cells (TCs) and extruding them from the vascular lumen while maintaining perfusion. In this work, we dissect the cellular and molecular mechanisms driving endothelial remodeling. Using high-resolution intravital imaging in zebrafish embryos, we demonstrate that the actomyosin network of ECs controls tissue remodeling and subsequent TC extravasation. Furthermore, we uncovered that this cytoskeletal remodeling is driven by altered endothelial-calcium (Ca²⁺) signaling caused b

SUBMITTER: Peralta M 

PROVIDER: S-EPMC11787530 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature