Anti-inflammatory activity and selective inhibition of iNOS gene expression by a polyherbal formulation.

ABSTRACT:

Background

Link Samahan® (LS), a product of Link Natural Products (Pvt) Limited, Sri Lanka contains extracts of 14 medicinal plants. It is used as a prophylactic against cold and cold related symptoms. It has immunomodulatory activity, specifically enhancing the humoral immune response.

Objective

To investigate the anti-inflammatory activity (AIA) of LS and related mechanisms.

Materials and methods

In vivo AIA was assessed by the inhibition of carrageenan-induced rat paw-edema. Mechanisms of AIA were assessed in vitro by the inhibition of reactive oxygen species (ROS) and reactive nitrogen species (RNS) production and expression of inducible nitric oxide synthase (iNOS) gene using rat peritoneal cells.

Results

LS showed an increasing inhibition in rat paw-edema

SUBMITTER: Ranaweera BVLR 

PROVIDER: S-EPMC11787581 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature