Reorganization of cortical individualized differential structural covariance network is associated with regional morphometric changes in chronic subcortical stroke.

ABSTRACT: Patients with chronic subcortical stroke undergo regional and network morphometric reorganizations beyond the lesion site, but the interplay between network and regional reorganization remains poorly understood. We aimed to clarify the reorganization patterns of the individualized differential structural covariance networks (IDSCN) in chronic subcortical stroke and investigate their associations with regional gray matter volume (GMV) changes and functional recovery. Structural MRI from four datasets enrolled 112 patients with chronic subcortical stroke (81 male, age: 55.82 ± 7.79) and 122 matched healthy controls (HC) (74 male; age: 55.28 ± 7.54). Network-based statistics were employed to identify aberrant IDSCN, Spearman correlation was conducted to assess the association between IDSCN an

SUBMITTER: Zhang H 

PROVIDER: S-EPMC11787593 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature