Middle-age cerebral small vessel disease and cognitive function in later life: a population-based prospective cohort study.

ABSTRACT:

Background

Cerebral small vessel disease (cSVD) is a major pathologic substrate of vascular contribution to cognitive impairment. However, population based long-term longitudinal cognitive function data in relation to cSVD are rare. We investigated the relationship between cSVD and cognitive decline over time in middle-aged through elderly population.

Methods

This prospective cohort study was conducted in a community-based adult population (avg. age 58.5 ± 6.4) who underwent both magnetic resonance imaging (MRI) and comprehensive neuropsychological tests at baseline (2011-2014). The participants were followed-up with the same neuropsychological test battery 4-yearly in two more cycles (in 2015-2018 and 2019-2022). A total of 2454 participants who were free of dementia and ce

SUBMITTER: Siddiquee AT 

PROVIDER: S-EPMC11787597 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature