Valproic acid intoxication - The importance of toxicological analysis and correct management: A case report.

ABSTRACT:

Introduction

Valproic acid (VPA) is an anticonvulsant widely used in treating epilepsy which can occur cases of poisoning in overdose situations.

Case description

A 15-year-old girl purposely ingested about 100 drug tablets according to family members. Gastric lavage with activated charcoal was performed at home using a nasogastric tube and patient just was taken to the hospital around 10 h after drug ingestion, arriving in shock state. All laboratorial parameters were altered together a suspect of aspiration pneumonia with the presence of gross perihilar infiltrated in the right lung. Immunoassay screening test did not detect any substance; LC-UV detected quetiapine (> 150 ng/mL) while GC-MS determined 977.96 µg/mL of valproic acid in the patient's plasma, confirming valpro

SUBMITTER: de Bairros AV 

PROVIDER: S-EPMC11787603 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature