BV/ODV-E26 is a conserved baculoviral inhibitory factor for optimizing viral virulence in lepidopteran hosts.

ABSTRACT: Alphabaculoviruses induce abnormal behavior in lepidopteran larval hosts. A baculoviral gene, bv/odv-e26, is crucial for behavioral manipulation in Bombyx mori larvae by Bombyx mori nucleopolyhedrovirus (BmNPV). However, how bv/odv-e26 fulfills its role in this phenotype remains largely unknown. In this study, we found that the overexpression of BmNPV bv/odv-e26 delayed viral infection in cultured cells and decreased pathogenicity in B. mori larvae. We also discovered that homologs of bv/odv-e26 are conserved more widely in alphabaculoviruses than previously thought. The inhibitory activity was demonstrated in bv/odv-e26 homologs of phylogenetically close and distant baculoviruses, indicating conserved inhibitory function among alphabaculovi

SUBMITTER: Hikida H 

PROVIDER: S-EPMC11787618 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature