Association between myopia and diabetic retinopathy: A two-sample mendelian randomization study.

ABSTRACT:

Objective

The association between myopia and diabetic retinopathy (DR) is unclear, with inconsistent results reported, and whether the association represents causality remains unknown. This study aimed to investigate the causal associations of genetically determined myopia with DR, and further explore specific mechanisms.

Methods

We conducted two-sample mendelian randomization (MR) analyses of any myopia and high myopia on six DR phenotypes, including any DR, background DR, severe background DR, proliferative DR (PDR), diabetic maculopathy and unspecific DR in the primary study. Mechanism exploration of spherical equivalent refraction (SER), corneal curvature (CC) and axial length (AL) on any DR was carried out subsequently. Single-nucleotide polymorphisms (SNPs), used as ge

SUBMITTER: Xu J 

PROVIDER: S-EPMC11787657 | biostudies-literature | 2025 Feb-Mar

REPOSITORIES: biostudies-literature