Adaptive radiotherapy in locally advanced head and neck cancer: The importance of reduced margins.

ABSTRACT:

Background and purpose

Adaptive radiotherapy (ART) involves treatment re-planning based on anatomical changes, which may improve target coverage and sparing of organs-at-risk (OARs). This study retrospectively assessed the technical feasibility and potential benefits of daily ART in combination with reduced planning target volume (PTV) margins for head and neck squamous cell carcinoma (HNSCC).

Materials and methods

Thirty-one patients, encompassing 902 treatment fractions, treated with radiotherapy to 60.0-68.0 Gy in 2 Gy/fraction were studied. Synthetic CTs (sCT) from daily kVCT images were created and contours propagated using deformable image registration (DIR). Target contours were reviewed and corrected. On the sCT, non-adapted delivered doses and ART-plans with 5 mm (c

SUBMITTER: Enocson H 

PROVIDER: S-EPMC11787698 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature