Safety, tolerability and pharmacokinetics of subcutaneous cefazolin as an alternative to intravenous administration.

ABSTRACT:

Background

Subcutaneous (SC) administration of antibiotics is a practical alternative to IV administration. Cefazolin is widely used for skin and soft tissue infections and other complex infections by IV administration.

Methods

In this prospective, cross-over self-controlled study, a single dose of SC cefazolin was administered to 15 stable inpatients established on IV cefazolin as part of their management plan. The equivalent dose of cefazolin was diluted in 50 mL of normal saline via gravity feed over 30 min. Venous blood samples were collected at baseline and 0.5, 1, 2, 4 and 8 h following both the SC and IV doses. Antibiotic concentrations were measured using UPLC-MS/MS. Pharmacokinetic data were analysed using a non-linear mixed-effects modelling approach. Pain scores a

SUBMITTER: Murray F 

PROVIDER: S-EPMC11787891 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature