Prenatal ozone exposure and child lung function: Exploring effect modification by oxidative balance score.

ABSTRACT:

Background

Prenatal exposures to ozone (O₃) may impact child lung function, including through oxidative stress pathways, contributing to lifelong morbidity. Diet, reflected in oxidative balance scores (OBS), may modify these pathways and is a potential target for interventions to mitigate O₃ effects.

Methods

We examined associations between prenatal exposure to O₃ and child lung function at age 8-9 years via spirometry in the CANDLE cohort within the ECHO-PATHWAYS Consortium. O₃ was estimated using a point-based spatiotemporal model and averaged over fetal morphological lung development phases: pseudoglandular, canalicular, and saccular. Lung function z-scores were calculated for FEV₁, FVC, FEV₁/FVC, and FEF

SUBMITTER: Dearborn LC 

PROVIDER: S-EPMC11788037 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature