A mouse model of immunosuppression facilitates oral <i>Candida albicans</i> biofilms, bacterial dysbiosis and dissemination of infection.

ABSTRACT: Opportunistic pathogens are a major threat to people, especially those with impaired immune systems. Two of the most important microbes in this category are the fungus Candida albicans and Gram-positive bacteria of the genus Enterococcus, which share overlapping niches in the oral cavity, gastrointestinal and urogenital tracts. The clinical importance of oral C. albicans biofilm and its interaction with the host under immunosuppressive conditions remains largely understudied. Here, we used a mouse model of oropharyngeal candidiasis (OPC) with cortisone acetate injection on alternate days and a continuous supply of C. albicans in drinking water for three days, resulting in immunosuppression. Results showed abundant growth of resident oral bacteria and a strong

SUBMITTER: Veerapandian R 

PROVIDER: S-EPMC11788080 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature