Extra-axial inflammatory signal and its relationship to peripheral and central immunity in depression.

ABSTRACT: Although both central and peripheral inflammation have been observed consistently in depression, the relationship between the two remains obscure. Extra-axial immune cells may play a role in mediating the connection between central and peripheral immunity. This study investigates the potential roles of calvarial bone marrow and parameningeal spaces in mediating interactions between central and peripheral immunity in depression. PET was used to measure regional TSPO expression in the skull and parameninges as a marker of inflammatory activity. This measure was correlated with brain TSPO expression and peripheral cytokine concentrations in a cohort enriched for heightened peripheral and central immunity comprising 51 individuals with depression and 25 healthy controls. The findings reveal a

SUBMITTER: Eiff B 

PROVIDER: S-EPMC11788198 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature