Epileptic activity on foramen ovale electrodes is associated with sleep and tau pathology in Alzheimer's disease.

ABSTRACT: Both sleep alterations and epileptiform activity are associated with the accumulation of amyloid-β and tau pathology and are currently investigated for potential therapeutic interventions in Alzheimer's disease. However, a bidirectional intertwining relationship between sleep and neuronal hyperexcitability might modulate the effects of Alzheimer's disease pathology on the corresponding associations. To investigate this, we performed multiple day simultaneous foramen ovale (FO) plus scalp EEG and polysomnography recordings and acquired 18F-MK6240 tau PET-MR in three patients in the prodromal stage of Alzheimer's disease and in two patients with mild and moderate dementia due to Alzheimer's disease, respectively. As an eligibility criterion for the present study, subjects either had a histor

SUBMITTER: Devulder A 

PROVIDER: S-EPMC11788210 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature