The graded multidimensional geometry of phenotypic variation and progression in neurodegenerative syndromes.

ABSTRACT: Clinical variants of Alzheimer's disease and frontotemporal lobar degeneration display a spectrum of cognitive-behavioural changes varying between individuals and over time. Understanding the landscape of these graded individual/group level longitudinal variations is critical for precise phenotyping; however, this remains challenging to model. Addressing this challenge, we leverage the National Alzheimer's Coordinating Center database to derive a unified geometric framework of graded longitudinal phenotypic variation in Alzheimer's disease and frontotemporal lobar degeneration. We included three time point, cognitive-behavioural and clinical data from 390 typical, atypical and intermediate Alzheimer's disease and frontotemporal lobar degeneration variants (114 typical Alzheimer's disease;

SUBMITTER: Ramanan S 

PROVIDER: S-EPMC11788217 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature