Detection and quantification of small and low-uptake lesions for differentiated thyroid carcinoma using non-time-of-flight iodine-124 PET/MRI.

ABSTRACT:

Background

124-iodine (¹²⁴I) is used for positron emission tomography (PET) diagnostics and therapy planning in patients with differentiated thyroid cancer (DTC). Small lesion sizes (<10 mm) and low ¹²⁴I uptake are challenging conditions for the detection of DTC lymph node lesions.

Purpose

The aim of this study was to systematically investigate the lesion detectability and quantification performance under clinically challenging imaging conditions using non-time-of-flight (TOF) PET/magnetic resonance imaging (MRI) in the clinical context of radionuclide therapy planning of DTC patients.

Methods

PET/MR measurements were performed on the Siemens Biograph mMR using a small lesion NEMA-like phantom (six glass spheres, diameters 3.7-9.7 mm). 60 min lis

SUBMITTER: Lindemann ME 

PROVIDER: S-EPMC11788235 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature