In-line spectroscopy for iodine quantification in dynamic contrast-enhanced dedicated breast CT.

ABSTRACT:

Background

In 4D dynamic contrast-enhanced dedicated breast computed tomography (4D DCE-bCT), the functional properties of the breast will be characterized by monitoring the uptake and washout of iodine-based contrast agents over time. This information could be valuable in breast cancer treatment. However, prior to clinical implementation, it is crucial to validate the quantitative estimates of iodine concentrations at each time point during acquisition.

Purpose

To develop an in-line spectroscopy system capable of measuring iodine concentrations in a dynamic x-ray breast phantom in real-time.

Methods

Potassium iodide served as the contrast agent. The system was set-up at both the entrance and exit of the phantom. It comprises a fiber-coupled green LED and collimator,

SUBMITTER: Goris LC 

PROVIDER: S-EPMC11788237 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature