Fundamental effects of array density and modulation frequency on image quality of diffuse optical tomography.

ABSTRACT:

Background

Diffuse optical tomography (DOT) provides three-dimensional image reconstruction of chromophore perturbations within a turbid volume. Two leading strategies to optimize DOT image quality include, (i) arrays of regular, interlacing, high-density (HD) grids of sources and detectors with closest spacing less than 15 mm, or (ii) source modulated light of order ∼100 MHz.

Purpose

However, the general principles for how these crucial design parameters of array density and modulation frequency may interact to provide an optimal system design have yet to be elucidated.

Methods

Herein, we systematically evaluated how these design parameters effect image quality via multiple key metrics. Specifically, we simulated 32 system designs with realistic measurement noise and

SUBMITTER: Fan W 

PROVIDER: S-EPMC11788260 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature