Brain function abnormalities and inflammation in HIV-positive men who have sex with men with depressive disorders.

ABSTRACT:

Background

Depressive disorders are highly prevalent among people with HIV (PWH) and are related to aberrant inflammation and immune responses. However, there is currently a lack of investigation into the neurological, inflammatory, endocrine, and immune aspects of HIV-associated depressive disorders (HADD).

Methods

The study involved 33 HIV-positive men who have sex with men with depressive disorders (HADD group) and 47 without neuropsychiatric disorders (HIV control group). Participants underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans and assessments of peripheral blood. Peripheral blood cytokines, plasma concentrations of hormone and neurotrophic factors, and immune cell levels were determined using liquid chip, enzyme-linked immunosorbent ass

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11788281 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature