Association between platelet count and 30-day in-hospital mortality among intensive care unit patients with sepsis: a multicenter retrospective cohort study.

ABSTRACT:

Background

The relationship between platelet count and sepsis outcomes in intensive care units (ICUs) requires comprehensive investigation through large-scale multicenter studies.

Methods

In this multicenter retrospective cohort study, we analyzed 17,977 sepsis patients from 208 U.S. hospitals (2014-2015) using the eICU Collaborative Research Database v2.0. Analyses were adjusted for demographics, clinical parameters, comorbidities, and treatments. Generalized additive models and two-piecewise linear regression were used to assess the relationship between platelet count and mortality.

Results

A U-shaped relationship was identified with an inflection point at 176 × 10⁹/L. Below this threshold, each 10 × 10⁹/L increase in platelet count was associated with a 6% decrease

SUBMITTER: Wang J 

PROVIDER: S-EPMC11788309 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature