Hypoxia signature derived from tumor-associated endothelial cells predict prognosis in gastric cancer.

ABSTRACT:

Background

A hypoxic metabolism environment in the tumors is often associated with poor prognostic events such as tumor progression and treatment resistance. In gastric cancer, the mechanism of how hypoxia metabolism affects the tumor microenvironment and immunotherapy efficacy remains to be elucidated.

Methods

We used the bulk-mapping method to analyze the signatures correlated with the response of immunotherapy in the single-cell dataset. Cellular, pathway, and gene were systematically analyzed in both single-cell and bulk validation datasets.

Results

The most significant cell proportion difference between the response and non-response groups was in endothelial cells, which represent the malignant cells. VWF was specifically overexpressed in endothelial cells and wa

SUBMITTER: Wang R 

PROVIDER: S-EPMC11788339 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature