α-methyltryptophan-mediated protection against diabetic nephropathy in <i>db/db</i> mice as studied with a metabolomics approach.

ABSTRACT:

Introduction

Diabetic nephropathy (DN), a major complication of diabetes, presents with poor clinical outcomes and affects patients throughout their lifetime. α-Methyltryptophan (α-MT) is a blocker of the amino acid transporter. SLC6A14 and also an inhibitor of indoleamine 2,3-dioxygenase-1 (IDO1).

Methods

In this study, we employed a nuclear magnetic resonance-based metabolomic approach to investigate the therapeutic effects of α-MT in a db/db mouse model of DN and explore the underlying molecular mechanisms.

Results

The results of the study demonstrated that α-MT significantly reduced the urinary excretion of albumin and creatinine, improved kidney function, and decreased renal fibrosis in db/db mice. Metabolomic analyses of kidney tissues and urine sa

SUBMITTER: Cai A 

PROVIDER: S-EPMC11788373 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature