The role of isoniazid dosage and NAT2 gene polymorphism in the treatment of tuberculous meningitis.

ABSTRACT:

Background

Tuberculous meningitis (TBM) is a non-purulent inflammatory condition affecting the meninges and spinal membranes, caused by Mycobacterium tuberculosis (MTB) infection. This study seeks to explore the impact of varying INH dosages and NAT2 gene polymorphisms on TBM treatment, contributing new insights to improve clinical management and patient prognosis.

Methods

Patients with TBM hospitalized between July 2020 and December 2022 were categorized into two groups based on INH dosage: the standard-dose group (300 mg/day) and the high-dose group (600 mg/day). General and baseline data were collected, and NAT2 genotypes were identified using real-time fluorescent PCR with melting curve analysis. The clinical characteristics and outcomes of patients with TBM under varyin

SUBMITTER: Jian Y 

PROVIDER: S-EPMC11788379 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature