Association of serum neurofilament light chain with cognitive impairment: findings from the National Health and Nutrition Examination Survey.

ABSTRACT:

Background

Serum Neurofilament Light chain (NfL) is a promising biomarker of neuronal damage, used to assess the extent of neuronal injury and neurodegeneration, and it is widely applied in the diagnosis of neurodegenerative disease and monitoring disease progression. This article aims to determine whether serum NfL associated with cognitive level.

Methods

Using NHANES data, we conducted an analysis of cognitive test results for 450 adults aged 60 years and older and examined their correlation with serum NfL levels. When exploring the association between cognitive test scores and serum NfL levels, regression models and restricted cubic spline (RCS) regression models were employed to adjust for potential confounding factors. The least absolute shrinkage and selection operator

SUBMITTER: Meng T 

PROVIDER: S-EPMC11788381 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature