Molecular insights into the elevator-type mechanism of the cyanobacterial bicarbonate transporter BicA.

ABSTRACT: Cyanobacteria are responsible for up to 80% of aquatic carbon dioxide fixation and have evolved a specialized carbon concentrating mechanism to increase photosynthetic yield. As such, cyanobacteria are attractive targets for synthetic biology and engineering approaches to address the demands of global energy security, food production, and climate change for an increasing world's population. The bicarbonate transporter BicA is a sodium-dependent, low-affinity, high-flux bicarbonate symporter expressed in the plasma membrane of cyanobacteria. Despite extensive biochemical characterization of BicA, including the resolution of the BicA crystal structure, the dynamic understanding of the bicarbonate transport mechanism remains elusive. To this end, we have collected over 1 ms of all-atom molecu

SUBMITTER: Chan MC 

PROVIDER: S-EPMC11788499 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature