Tranexamic acid to prevent bleeding after endoscopic resection of large colorectal polyps: a pilot project.

ABSTRACT:

Background and aims

Delayed post-polypectomy bleeding (DPPB) can occur up to a month following the procedure but is typically seen within the first week. Tranexamic acid (TXA) is a member of a class of drugs called antifibrinolytic agents. It reduces fibrinolysis by slowing down the conversion of plasminogen to plasmin, which may prevent bleeding. The goal of this pilot study is to assess the feasibility of using tranexamic acid after endoscopic mucosal resection (EMR) of large (≥2 cm) non-pedunculated colorectal polyps (LNPCPs) to prevent DPPB.

Methods

This was a single centre feasibility study conducted at the Kingston Health Sciences Centre in 2021. After the polypectomy was completed, IV tranexamic acid was given [1 gram of TXA in 100 mL of normal saline] and infused ove

SUBMITTER: Rai M 

PROVIDER: S-EPMC11788509 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature