Identification and Potential Clinical Utility of Common Genetic Variants in Gestational Diabetes among Chinese Pregnant Women.

ABSTRACT:

Backgruound

The genetic basis for hyperglycaemia in pregnancy remain unclear. This study aimed to uncover the genetic determinants of gestational diabetes mellitus (GDM) and investigate their applications.

Methods

We performed a meta-analysis of genome-wide association studies (GWAS) for GDM in Chinese women (464 cases and 1,217 controls), followed by de novo replications in an independent Chinese cohort (564 cases and 572 controls) and in silico replication in European (12,332 cases and 131,109 controls) and multi-ethnic populations (5,485 cases and 347,856 controls). A polygenic risk score (PRS) was derived based on the identified variants.

Results

Using the genome-wide scan and candidate gene approaches, we identified four susceptibility loci for GDM. These include

SUBMITTER: Tam CH 

PROVIDER: S-EPMC11788552 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature