Impact of in-hospital medication changes on clinical outcomes in older inpatients: the journey and destination.

ABSTRACT:

Background

Medication review is integral in the pharmacological management of older inpatients.

Objective

To assess the association of in-hospital medication changes with 28-day postdischarge clinical outcomes.

Methods

Retrospective cohort of 2000 inpatients aged ≥75 years. Medication changes included the number of increases (medications started or dose-increased) and decreases (medications stopped or dose-decreased) for (i) all medications, (ii) Drug Burden Index (DBI)-contributing medications and (iii) Beers Criteria 2015 medications (potentially inappropriate medications, PIMs). Changes also included differences in (i) the number of medications, (ii) the number of PIMs and (iii) DBI score, at discharge versus admission. Associations with clinical outcomes (28-day E

SUBMITTER: Masnoon N 

PROVIDER: S-EPMC11788564 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature