Accumulation of advanced oxidation protein products aggravates bone-fat imbalance during skeletal aging.

ABSTRACT:

Background

Skeletal aging is characterized by a decrease in bone mass and an increase in marrowfat content. Advanced oxidation protein products (AOPPs) accumulate easily with aging and disrupt redox homeostasis. We examined whether AOPPs accumulation contributes to the bone-fat imbalance during skeletal aging.

Methods

Both young and aged mice were employed to assess the changes of AOPPs levels and its contribution to bone-fat imbalance during skeletal aging. Primary bone marrow mesenchymal stromal cells (MSCs) were used to examine the potential role of AOPPs in age-related switch between osteogenic and adipogenic differentiation. Aged mice were also gavaged by non-selective antioxidant N-acetyl-L-cysteine (NAC), followed by close monitoring of the changes in AOPPs levels and

SUBMITTER: Huang YS 

PROVIDER: S-EPMC11788738 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature