Physiological effects of high-flow nasal cannula during sustained high-intensity exercise in healthy volunteers: a randomised crossover trial.

ABSTRACT:

Introduction

High-flow nasal cannula (HFNC) has increased exercise capacity in patients with chronic respiratory diseases. However, it remains unknown whether HFNC impacts respiratory physiological variables during exercise. This study aimed to evaluate the effect of HFNC on respiratory physiological variables during sustained high-intensity exercise in healthy volunteers.

Methods

We performed a single-centre, open-label, randomised crossover trial to compare HFNC (60 L·min^-1) and Sham-HFNC (2 L·min^-1) interventions during a constant work rate exercise (CWRET) through randomised order. The primary outcome was change in oesophageal pressure (ΔP _oes), and the secondary outcomes were other variables of inspiratory effort, ventilation dist

SUBMITTER: Moya-Gallardo E 

PROVIDER: S-EPMC11788807 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature