Phenome-wide association studies between SERINC2 and neuropsychiatric disorders.

ABSTRACT:

Objectives

SERINC2 has been associated with alcoholism, bipolar disorder and autism, but the comparability and specificity issues of the findings remain unaddressed. The present study aimed to comprehensively analyze various neuropsychiatric disorders pinpoint the most reliable conditions predisposed by SERINC2.

Methods

A total of 2,187 imputed SNPs across SERINC2 were examined in 1,167,439 subjects from 72 independent cohorts with 18 different neuropsychiatric disorders. SNP-disease associations were tested and then meta-analyzed, followed by FDR correction, to identify significant disease-risk SNPs. Finally, functional studies on the differential SERINC2 mRNA expression in brains and the potential regulatory effects of disease-risk alleles on

SUBMITTER: Liu P 

PROVIDER: S-EPMC11788846 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature