Single-cell sequencing revealed the necessity of macrophages in brain microenvironment remodeling by breast cancer metastasis.

ABSTRACT: Breast cancer is one of the most common cancers worldwide, 30-50 % of patients with advanced breast cancer develop brain metastasis, causing severe damage to their life quality. Due to the existence of the blood-brain barrier (BBB), brain lesions were recognized to be a unique microenvironment with limited infiltration of circulating immune cells and drugs. However, emerging studies reported the immunology of the brain tumor microenvironment (TME) and indicated the potential of immunotherapy against brain metastases. Therefore, it is of great value to comprehensively investigate the TME and identify the pro-tumoral mechanisms facilitating brain metastases and the crucial molecules involved in this process. In this research, we re-analyzed public data on three brain surgical specimens of br

SUBMITTER: Liu M 

PROVIDER: S-EPMC11788856 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature