Features of gastrointestinal acute graft-versus-host disease in children undergoing hematopoietic stem cell transplantation.

ABSTRACT:

Objectives

Graft-versus-host disease (GVHD) commonly affects the gastrointestinal (GI) tract among children who undergo hematopoietic stem cell transplantation (HSCT). Studies concerning GI-acute GVHD (aGVHD) in developing countries are limited. Therefore, our aims were (1) to demonstrate clinical characteristics, endoscopic and histopathological findings in children with GI-aGVHD post-HSCT and (2) to compare features, risk factors, and clinical outcomes of children with GI-aGVHD versus non GI-aGVHD.

Methods

A retrospective single-center study was conducted on patients receiving the first successful HSCT aged <20 years old between January 2011 and December 2020. The patients were divided into groups with GI-aGVHD (clinically or endoscopy-histopathologically diagnosed) and wi

SUBMITTER: Rattanaseksan K 

PROVIDER: S-EPMC11788946 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature