Relationship of Neurotropin-3 Gene Polymorphism with Cognitive Impairment in Bipolar Disorder.

ABSTRACT:

Background

Neurotropin-3 (NT-3), a marker of neural plasticity, is reported to be altered in bipolar disorder (BD). This study was designed to evaluate NT-3 gene polymorphism (rs 6489630, rs 6332, and rs 11063714) in BD and its association with disease severity and cognition.

Methods

The study included 176 BD cases and 176 controls. All the participants were tested for NT-3 polymorphism and plasma NT-3. ACE-III scores were used to analyze cognition.

Results

The NT-3 polymorphism (rs 6489630) was associated with cognitive impairment in BD (P = .010). The attention score was found to be decreased in the CT genotype (P = .028) when compared to the CC and TT genotypes of the rs6489630 variant. The visuospatial ability score was decreased in the GG genotype (

SUBMITTER: Monisha M 

PROVIDER: S-EPMC11789048 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature