Lipid-induced condensate formation from the Alzheimer's Aβ peptide triggers amyloid aggregation.

ABSTRACT: The onset and development of Alzheimer's disease is linked to the accumulation of pathological aggregates formed from the normally monomeric amyloid-β peptide within the central nervous system. These Aβ aggregates are increasingly successfully targeted with clinical therapies at later stages of the disease, but the fundamental molecular steps in early stage disease that trigger the initial nucleation event leading to the conversion of monomeric Aβ peptide into pathological aggregates remain unknown. Here, we show that the Aβ peptide can form biomolecular condensates on lipid bilayers both in molecular assays and in living cells. Our results reveal that these Aβ condensates can significantly accelerate the primary nucleation step in the amyloid conversion cascade that leads to the formation

SUBMITTER: Sneideriene G 

PROVIDER: S-EPMC11789053 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature