Transcriptomic analysis of Rhipicephalus microplus hemocytes from female ticks infected with Babesia bovis or Babesia bigemina.

ABSTRACT:

Background

Tick hemolymph is a sterile fluid that carries nutrients to maintain tick health. The hemolymph creates a hostile environment for invaders including the destruction of microorganisms by its circulating hemocytes. However, Babesia parasites escape and disseminate to other organs through the hemolymph to continue their transmission life cycle. Still, it is unknown how tick hemocytes respond to B. bovis or B. bigemina infection. In this study, we conducted a transcriptomic analysis of hemocytes from female Rhipicephalus microplus ticks infected with Babesia parasites to understand how gene expression changes during parasite infection.

Methods

During Babesia acute infection, female R. microplus ticks were fed on bovines to acquire parasites. Engorged females were coll

SUBMITTER: Vimonish R 

PROVIDER: S-EPMC11789329 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature