Cancer cells avoid ferroptosis induced by immune cells via fatty acid binding proteins.

ABSTRACT:

Background

Cancer creates an immunosuppressive environment that hampers immune responses, allowing tumors to grow and resist therapy. One way the immune system fights back is by inducing ferroptosis, a type of cell death, in tumor cells through CD8 ⁺ T cells. This involves lipid peroxidation and enzymes like lysophosphatidylcholine acyltransferase 3 (Lpcat3), which makes cells more prone to ferroptosis. However, the mechanisms by which cancer cells avoid immunotherapy-mediated ferroptosis are unclear. Our study reveals how cancer cells evade ferroptosis and anti-tumor immunity through the upregulation of fatty acid-binding protein 7 (Fabp7).

Methods

To explore how cancer cells resist immune cell-mediated ferroptosis, we used a comprehensive range of techniques. We

SUBMITTER: Freitas-Cortez MA 

PROVIDER: S-EPMC11789333 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature