Predictors of biochemical and structural response to medical therapy in patients with active acromegaly following surgery: a real-world perspective.

ABSTRACT:

Background

Somatostatin receptor analogs (SRAs) and dopamine agonists (DAs) are the main medical treatments for patients with acromegaly who fail to achieve remission after surgery. We aimed to explore the potential role of select clinical, biochemical, and radiological factors in predicting biochemical and structural responses to medical therapy in a real-world setting.

Methods

This retrospective cohort study included 58 patients with active acromegaly following surgery treated with Octreotide long-acting release (LAR) (± Cabergoline). Biochemical outcomes were defined as the tight biochemical response (TBR; normal insulin-like growth factor-1(IGF-1)) and biochemical control (BC; IGF-1 ≤ 1.2 upper limit of normal (ULN)). The structural response was defined as > 25% reductio

SUBMITTER: Rafieemanesh M 

PROVIDER: S-EPMC11789350 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature